feature photo

 

Clinical Trials and Research

What is a clinical trial?

A clinical trial is a medical research study in humans that looks for ways to treat a particular condition.
A clinical trial is carefully controlled and follows specific protocols. A clinical trial can examine the safety and/or the effectiveness of a particular treatment. These treatments can be medications, medical treatments or device treatments. The only way for a clinical trial to be successful is to have people who are willing to participate. Participants can help further medical knowledge and potentially help other people.

What clinical trials is the USC Neurology Department conducting?

Currently, we are conducting inpatient and outpatient stroke clinical trials, movement disorder clinical trials, and multiple clinical trials involving various other neurological disorders as well.

Current Clinical Trials

Current Clinical Trials
PDPN:  A Double-Blind, Placebo-Controlled, Feasibility Study to Examine the Efficacy of Topical Cream as Add-On Therapy in Painful Diabetic Peripheral Neuropathy Patients
Funded by:  University of South Carolina: Clinical Incentive Grant
Principal Investigator:  James Selph, MD
Contact: Johann Fridriksson, MSPH: 803-545-6078
Currently Enrolling

Determination of the Epigenetic Changes Related to Inflammation in Stroke Patients

Funded by: South Carolina Center of Economic Excellence (COEE)
Principal Investigator:  Souvik Sen, MD and Mitzi Nagarkatti, PhD
Contact:  Joselyn Burdine, MSPH, CPH:  803-545-6060
Currently Enrolling

MS Immune:  Immunological Studies in Patients with Multiple Sclerosis 

Funded by: University of South Carolina
Site Investigators:  Davit Mrelashvili, MD and Mitzi Nagarkatti, PhD
Contact:  Johann Fridriksson, MSPH:  803-545-6078
Currently Enrolling

IRIS:  Insulin Resistance Intervention after Stroke Trial 

Funded by: National Institute of Neurological Disorders and Stroke (NINDS) and PhotoThera Inc., National Institute of Health (NIH), Yale University
Site Principal Investigator:  Souvik Sen, MD
Contact:  Johann Fridriksson, MSPH:  803-545-6078
Website: iristrial.org
      
STRATIFY-2:  JCV Antibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment with Tysabri®  
Funded by: Biogen Idec.
Site Principal Investigator:  Davit Mrelashvili, MD              
Contact:  Johann Fridriksson, MSPH:  803-545-6078

The Effect of Cerebral Reperfusion on Brain Connectivity in Acute Stroke
Funded by: University of South Carolina clinical Incentive Grant
Site Principal Investigator:  Souvik Sen, MD
Contact:  Joselyn Burdine, MSPH, CPH:  803-545-6060

Prospective Propensity Score Based Registry Testing Comparative Effectiveness of Secondary Prevention Medications Used in Ischemia Stroke/TIA Patients
Funded by:  Institute for Advancement of Health Care (IAHC)
Site Principal Investigator:  Souvik Sen, MD
Contact:  Joselyn Burdine, MSPH, CPH:  803-545-6060

DIAS-4:  A Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Phase III Study to Evaluate the Efficacy and Safety of Desmoteplase in Subjects with Acute Ischemic Stroke 
Funded by: H. Lundbeck A/S
Site Principal Investigator:  Souvik Sen, MD
Contact:  803-434-2884, Research-Research-Assist@PalmettoHealth.org

Multistem:  Double-Blind, Randomized, Placebo-Controlled Phase 2 Safety and Efficacy Trial of MultiStem in Adults with Ischemic Stroke 
Funded by:  Athersys. Inc.
Site Principal Investigator:  Souvik Sen, MD
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org

POINT: Platelet Oriented Inhibition in New TIA and Minor Stroke Trial
Funded by: University of California at San Francisco/NINDS/NIH
Site Principal Investigator:  Souvik Sen, MD
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org
Website: pointtrial.org

ATACH-II:  Antihypertensive Treatment of Acute Cerebral Hemorrhage 

Funded by:  University of Minnesota/NINDS/NIH                              
Site Principal Investigator:  Souvik Sen, MD                                                         
Contact:   803-434-2884, Research-Assist@PalmettoHealth.org
Website: atach2.com

IMPACT 24B:   Multicenter, Randomized, Double-Blind, Sham Control, Parallel Arm Trial to Assess Effectiveness and Safety of the Ischemic Stroke System ISS, as an Adjunct to Standard of Care in Subjects with Acute Ischemic Stroke 

Funded by:  BrainsGate Ltd.
Site Principal Investigator:  Souvik Sen, MD
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org

What other neurology research studies are there at the University of South Carolina?

The Neurology Department is currently collaborating with the Physical Therapy Program and the Aphasia group on Stroke research studies. Below is the contact information to learn more about these studies.

Collaborative Research Studies

Aphasia Stroke Research
Department of Communication Sciences and Disorders
Contact: (803) 777-2693
Website: Aphasia Stroke Research
For information on ongoing clinical trials at Palmetto Health Richland, you can visit:
Palmetto Health Richland Clinical Treatment Trials