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Clinical Trials and Research

What is a clinical trial?
A clinical trial is a medical research study in humans that looks for ways to treat a particular condition. 
A clinical trial is carefully controlled and follows specific protocols. A clinical trial can examine the safety and/or the effectiveness of a particular treatment. These treatments can be medications, medical treatments or device treatments. The only way for a clinical trial to be successful is to have people who are willing to participate. Participants can help further medical knowledge and potentially help other people.

What clinical trials is the USC Neurology Department conducting?
Currently, we are conducting inpatient and outpatient stroke clinical trials, movement disorder clinical trials, and multiple clinical trials involving various other neurological disorders as well.

Current Clinical Trials

SC-CoAST: South Carolina Collaborative Alliance for Stroke Trials
Funded by:  National Institute of Neurological Disease and Stroke (NINDS) 
Site Investigator:  Souvik Sen, MD
Contact: Lauren Dennis, MHA: 803-545-6078

PRISM: Potential of rtPA for Ischemic Strokes with Mild Symptoms

Funded by: Genetech
Principal Site Investigator:  Souvik Sen, MD  
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org

SOCRATES: Acute Stroke or Transient Ischemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes
Funded by: Astra-Zeneca
Site Investigators:  Michelle Androulakis, MD, Souvik Sen, MD
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org


IRIS:  Insulin Resistance Intervention after Stroke Trial  

Funded by: National Institute of Neurological Disorders and Stroke (NINDS) and PhotoThera Inc., National Institute of Health (NIH), Yale University
Site Principal Investigator:  Souvik Sen, MD
Contact:  Kaitlin Krebs, MA:  803-545-6060
Website: iristrial.org
   

CLOTBUST-ER: Phase 3, Randomized, Placebo-Controlled, Double-Blinded Trial of the Combined Lysis of Thrombus with Ultrasound and Systemic Tissue Plasminogen Activator (tPA) for Emergent Revascularization in Acute Ischemic Stroke   
Funded by: Cerevast Therapeutics Inc.
Site Principal Investigator:  Souvik Sen, MD               
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org

Multistem:  Double-Blind, Randomized, Placebo-Controlled Phase 2 Safety and Efficacy Trial of MultiStem in Adults with Ischemic Stroke  
Funded by:  Athersys. Inc.
Site Principal Investigator:  Souvik Sen, MD
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org

POINT: Platelet Oriented Inhibition in New TIA and Minor Stroke Trial 
Funded by: University of California at San Francisco/NINDS/NIH
Site Principal Investigator:  Souvik Sen, MD
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org
Website: pointtrial.org 

ATACH-II:  Antihypertensive Treatment of Acute Cerebral Hemorrhage  

Funded by:  University of Minnesota/NINDS/NIH
Site Principal Investigator:  Souvik Sen, MD
Contact:   803-434-2884,
Research-Assist@PalmettoHealth.org 
Website: atach2.com 

IMPACT 24B:   Multicenter, Randomized, Double-Blind, Sham Control, Parallel Arm Trial to Assess Effectiveness and Safety of the Ischemic Stroke System ISS, as an Adjunct to Standard of Care in Subjects with Acute Ischemic Stroke  

Funded by:  BrainsGate Ltd.
Site Principal Investigator:  Souvik Sen, MD
Contact:  803-434-2884, Research-Assist@PalmettoHealth.org 

What other neurology research studies are there at the University of South Carolina?
 
The Neurology Department is currently collaborating with the Physical Therapy Program and the Aphasia group on Stroke research studies. Below is the contact information to learn more about these studies. 

Collaborative Research Studies

Aphasia Stroke Research
Department of Communication Sciences and Disorders 
Contact: (803) 777-2693 
Website: Aphasia Stroke Research 
For information on ongoing clinical trials at Palmetto Health Richland, you can visit: 
Palmetto Health Richland Clinical Treatment Trials